Murck H, Guldner J, Colla-Müller M, Frieboes R M, Schier T, Wiedemann K, Holsboer F, Steiger A
Department of Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
Am J Physiol. 1996 Oct;271(4 Pt 2):R905-11. doi: 10.1152/ajpregu.1996.271.4.R905.
Centrally administered vasoactive intestinal polypeptide (VIP) promotes rapid eye movement (REM) sleep in rats, rabbits, and cats. We studied the effect of 4 x 10 micrograms VIP (expt 1, n = 7) and 4 x 50 micrograms VIP (expt 2, n = 10) administered hourly as intravenous boluses between 2200 and 0100 on sleep electroencephalogram and secretion of plasma adreno corticotropic hormone, cortisol, growth hormone, and prolactin in humans. In experiment 2, the sleep cycles were decelerated during the first three cycles because of increased duration of both REM and non-REM sleep periods, and there was a tendency to increased REM-to-non-REM ratios. With a low VIP dose, prolactin levels were decreased during the whole night, whereas, with a high dose, they were increased during the first half of the night. In experiment 2, the cortisol nadir was advanced, after midnight the serum cortisol levels were enhanced, and the growth hormone peak was blunted. It appears that VIP may have a phase-advancing effect on sleep cycles and cortisol secretion, possibly through actions that involve the suprachiasmatic nucleus.
中枢给予的血管活性肠肽（VIP）可促进大鼠、兔子和猫的快速眼动（REM）睡眠。我们研究了在22:00至01:00之间每小时静脉推注4×10微克VIP（实验1，n = 7）和4×50微克VIP（实验2，n = 10）对人类睡眠脑电图以及血浆促肾上腺皮质激素、皮质醇、生长激素和催乳素分泌的影响。在实验2中，由于REM睡眠期和非REM睡眠期的持续时间增加，在前三个睡眠周期中睡眠周期减慢，并且REM与非REM的比例有增加的趋势。低剂量VIP时，催乳素水平在整个夜间降低，而高剂量时，催乳素水平在上半夜升高。在实验2中，皮质醇最低点提前，午夜后血清皮质醇水平升高，生长激素峰值变钝。看来VIP可能对睡眠周期和皮质醇分泌有相位提前作用，可能是通过涉及视交叉上核的作用实现的。
