Sandborgh-Englund G, Nygren A T, Ekstrand J, Elinder C G
Department of Dental Toxicology, Karolinska Institute, Huddinge, Sweden.
Am J Physiol. 1996 Oct;271(4 Pt 2):R941-5. doi: 10.1152/ajpregu.1996.271.4.R941.
Dental amalgam continuously releases mercury. Studies of sheep [Boyd et al., Am. J. Physiol. 261 (Regulatory Integrative Comp. Physiol. 30): R1010-R1014, 1991] showed decreased renal function after placement of amalgam fillings. In this study, renal function was investigated in 10 healthy volunteers before and after amalgam removal. The subjects had an average of 18 tooth surfaces filled with amalgam, which was removed during one dental session. One week before and sixty days after removal, the glomerular filtration rate (GFR) was determined by 51Cr-EDTA clearance technique. Blood and urine samples were collected for analysis of mercury, creatinine, beta 2-microglobulin, N-acetyl-beta-glucosaminidase (NAG), and albumin 1 wk before and 1, 2, and 60 days after amalgam removal. The plasma mercury concentration increased significantly 1 day after removal. Sixty days later, significantly lower mercury levels were found in blood, plasma, and urine. The GFR values were similar before and after mercury exposure (mean 94 and 94 ml/min per 1.73 m2, respectively). No detectable effects occurred on excretion of NAG, beta 2-microglobulin, or albumin. It is concluded that no signs of renal toxicity could be found in conjunction with mercury released from amalgam fillings.
牙科汞合金会持续释放汞。对绵羊的研究[博伊德等人，《美国生理学杂志》261卷（调节整合与比较生理学30）：R1010 - R1014，1991年]表明，放置汞合金填充物后肾功能会下降。在本研究中，对10名健康志愿者在去除汞合金填充物前后的肾功能进行了调查。这些受试者平均有18个牙面填充了汞合金，在一次牙科治疗过程中被去除。在去除前一周和去除后60天，通过51Cr - EDTA清除技术测定肾小球滤过率（GFR）。在去除汞合金前1周以及去除后1天、2天和60天采集血液和尿液样本，用于分析汞、肌酐、β2 - 微球蛋白、N - 乙酰 - β - 氨基葡萄糖苷酶（NAG）和白蛋白。去除后1天血浆汞浓度显著升高。60天后，血液、血浆和尿液中的汞水平显著降低。汞暴露前后的GFR值相似（分别平均为每1.73平方米94和94毫升/分钟）。未发现对NAG、β2 - 微球蛋白或白蛋白排泄有可检测到的影响。结论是，未发现与汞合金填充物释放的汞相关的肾毒性迹象。
