Herrström P, Schütz A, Raihle G, Holthuis N, Högstedt B, Råstam L
Primary Care Center Hertig Knut Halmstad, Sweden.
Arch Environ Health. 1995 Mar-Apr;50(2):103-7. doi: 10.1080/00039896.1995.9940886.
Chronic exposure to inorganic mercury can cause kidney injury. Evidence gained from occupational medicine indicates that individuals who are exposed to only environmental sources, including amalgam tooth fillings, are at very little risk. Animal experiments, however, have revealed glomerular lesions of immunologic origin after low-dose exposure to inorganic mercury. In this study, the association between the number of amalgam tooth surfaces, urinary mercury, and proteinuria was explored in a sample of 48 randomly selected, apparently healthy male students who were 17-22 y of age. Presence of any of the following proteins in two separate urine samples was considered to be potentially indicative of any tubular and/or glomerular lesion: albumin, alpha-1-microglobulin (HC-protein), kappa and lambda light chains, and N-acetyl-beta-D-glucosaminidase. No significant relationship was found between any of the proteins and amalgam or urinary mercury. The results of this study did not suggest that amalgam fillings cause kidney dysfunction in humans.
长期接触无机汞会导致肾脏损伤。职业医学方面的证据表明，仅接触包括汞合金补牙材料在内的环境汞源的个体风险极小。然而，动物实验显示，低剂量接触无机汞后会出现免疫源性肾小球病变。在本研究中，对48名年龄在17至22岁之间、随机选取的表面健康的男性学生样本，探讨了汞合金牙面数量、尿汞与蛋白尿之间的关联。两份独立尿液样本中若存在以下任何一种蛋白质，则被认为可能表明存在肾小管和/或肾小球病变：白蛋白、α-1-微球蛋白（HC蛋白）、κ和λ轻链以及N-乙酰-β-D-氨基葡萄糖苷酶。未发现任何一种蛋白质与汞合金或尿汞之间存在显著关系。本研究结果并未表明汞合金补牙会导致人类肾功能障碍。
