Eti S, Weisman R, Hoffman R, Reidenberg M M
Department of Pharmacology, Cornell University Medical College, New York, NY 10021, USA.
Pharmacol Toxicol. 1995 Jan;76(1):47-9. doi: 10.1111/j.1600-0773.1995.tb00101.x.
The current study was to answer the question: Is enough mercury absorbed from dental amalgam fillings to produce renal damage? One hundred healthy adults (18-44 years old) filled out health questionnaires and voided urine samples. Urine mercury concentration and N-acetyl-beta-glucosaminidase (NAG) were measured. Subjects were grouped into those having amalgam fillings (N = 66) and those without (N = 34). Median (95% Confidence Interval) urine mercury was 1 (1-2) and 0 (0-0.6) ng/ml (P < 0.01) and median urine NAG was 23 (18-27) and 16 (11-18) units (P < 0.05) in the two groups respectively. People with mercury amalgam fillings excreted slightly more mercury than people without them, and have a very small increase in urinary NAG excretion that is probably of no clinical significance. This dose of mercury absorbed from amalgam appears to be too little to be a public health hazard for renal injury.
从银汞合金补牙材料中吸收的汞是否足以导致肾脏损伤？一百名健康成年人（年龄在18至44岁之间）填写了健康问卷并提供了尿液样本。测量了尿汞浓度和N-乙酰-β-葡萄糖苷酶（NAG）。受试者被分为有银汞合金补牙材料的组（N = 66）和没有银汞合金补牙材料的组（N = 34）。两组的尿汞中位数（95%置信区间）分别为1（1 - 2）和0（0 - 0.6）纳克/毫升（P < 0.01），尿NAG中位数分别为23（18 - 27）和16（11 - 18）单位（P < 0.05）。有银汞合金补牙材料的人排出的汞比没有的人略多，并且尿NAG排泄量有非常小的增加，这可能没有临床意义。从银汞合金中吸收的这种剂量的汞似乎太少，不足以对肾脏造成公共卫生危害。
