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产气气杆菌中腺苷钴胺素依赖性甘油脱水酶的作用机制研究。II. 甘油脱水酶与腺苷钴胺素及其类似物复合物的失活动力学

Study of the mechanism of action of adenosylcobalamindependent glycerol dehydratase from Aerobacter aerogenes. II. The inactivation kinetics of glycerol dehydratase complexes with adenosylobalamin and its analogs.

作者信息

Poznanskaya A A, Yakusheva M I, Yakovlev V A

出版信息

Biochim Biophys Acta. 1977 Sep 15;484(1):236-43. doi: 10.1016/0005-2744(77)90128-0.

DOI:10.1016/0005-2744(77)90128-0
PMID:889846
Abstract

The inactivation kinetics of vacterial glycerol dehydratase (EC 4.2.1.30) in the course of its reaction with adenosylcobalamin (AdoCbl) and its analogs were investigated. It was shown that the inactivation rate of apoenzyme complexes with AdoCbl analogs is determined by the nature of the analogs employed and probably by the rate of their conversion into hydroxycobalamins. A possible inactivation mechanism of glycerol dehydratase is discussed.

摘要

研究了细菌甘油脱水酶（EC 4.2.1.30）在与腺苷钴胺素（AdoCbl）及其类似物反应过程中的失活动力学。结果表明，脱辅基酶与AdoCbl类似物复合物的失活速率取决于所用类似物的性质，可能还取决于它们转化为羟基钴胺素的速率。讨论了甘油脱水酶可能的失活机制。

相似文献

1
Study of the mechanism of action of adenosylcobalamindependent glycerol dehydratase from Aerobacter aerogenes. II. The inactivation kinetics of glycerol dehydratase complexes with adenosylobalamin and its analogs.产气气杆菌中腺苷钴胺素依赖性甘油脱水酶的作用机制研究。II. 甘油脱水酶与腺苷钴胺素及其类似物复合物的失活动力学
Biochim Biophys Acta. 1977 Sep 15;484(1):236-43. doi: 10.1016/0005-2744(77)90128-0.
2
Study on the mechanism of action of adenosylcobalamin-dependent glycerol dehydratase from Aerobacter aerogenes. I. Role of structural components of adenosylcobalamin the formation of the active site of glycerol dehydratase.产气气杆菌中腺苷钴胺素依赖性甘油脱水酶的作用机制研究。I. 腺苷钴胺素的结构成分在甘油脱水酶活性位点形成中的作用。
Biochim Biophys Acta. 1977 Sep 15;484(1):216-35. doi: 10.1016/0005-2744(77)90127-9.
3
[9-(Adenylyl)alkylcobalamins as inhibitors of adenosylcobalamin-dependent glycerol dehydratase from Aerobacter aerogenes].[9-（腺苷酰基）烷基钴胺素作为产气气杆菌中腺苷钴胺素依赖性甘油脱水酶的抑制剂]
Biokhimiia. 1977 Nov;42(11):2086-8.
4
[Interaction of substrates and their analogs with adenosylcobalamine-dependent glycerol dehydratase].[底物及其类似物与腺苷钴胺素依赖性甘油脱水酶的相互作用]
Biokhimiia. 1979 Mar;44(3):467-76.
5
[Effect of environmental factors on inactivation of B12-dependent glycerol dehydratase from Aerobacter aerogenes].[环境因素对产气气杆菌中维生素B12依赖性甘油脱水酶失活的影响]
Biokhimiia. 1976;41(7):1297-1305.
6
[Effect of the structure of the nucleoside ligand of cobalamines on their enzymatic properties in a glycerol dehydratase system].
Biokhimiia. 1978 Oct;43(10):1873-82.
7
[Study of purine analogs of cobamide coezyme in a glycerol dehydratase system from aerobacter aerogenes].
Izv Akad Nauk SSSR Biol. 1974 Nov-Dec(6):867-77.
8
[Role of monovalent cations in reactions catalyzed by glycerol dehydrase from Aerobacter aerogenes].[单价阳离子在产气气杆菌甘油脱水酶催化反应中的作用]
Biokhimiia. 1975 May-Jun;40(3):559-65.
9
Distribution of coenzyme B12-dependent diol dehydratase and glycerol dehydratase in selected genera of Enterobacteriaceae and Propionibacteriaceae.辅酶B12依赖性二醇脱水酶和甘油脱水酶在肠杆菌科和丙酸杆菌科选定属中的分布。
J Bacteriol. 1980 Mar;141(3):1439-42. doi: 10.1128/jb.141.3.1439-1442.1980.
10
Mechanism of action of adenosylcobalamin: hydrogen transfer in the inactivation of diol dehydratase by glycerol.腺苷钴胺素的作用机制：甘油使二醇脱水酶失活过程中的氢转移
Biochemistry. 1978 May 30;17(11):2218-24. doi: 10.1021/bi00604a031.

引用本文的文献

1
Purification and Characterization of Glycerol Dehydratase from Lactobacillus reuteri.鼠李糖乳杆菌甘油脱水酶的纯化和性质研究。
Appl Environ Microbiol. 1990 Apr;56(4):1195-7. doi: 10.1128/aem.56.4.1195-1197.1990.
2
Production of 3-hydroxypropionaldehyde from glycerol.从甘油生产 3-羟基丙醛。
Appl Environ Microbiol. 1983 Jul;46(1):62-7. doi: 10.1128/aem.46.1.62-67.1983.
3
Identification of a reactivating factor for adenosylcobalamin-dependent ethanolamine ammonia lyase.腺苷钴胺素依赖性乙醇胺氨裂合酶再激活因子的鉴定
J Bacteriol. 2004 Oct;186(20):6845-54. doi: 10.1128/JB.186.20.6845-6854.2004.
4
Identification and characterization of coenzyme B12-dependent glycerol dehydratase- and diol dehydratase-encoding genes from metagenomic DNA libraries derived from enrichment cultures.从富集培养物来源的宏基因组DNA文库中鉴定和表征依赖辅酶B12的甘油脱水酶和二醇脱水酶编码基因。
Appl Environ Microbiol. 2003 Jun;69(6):3048-60. doi: 10.1128/AEM.69.6.3048-3060.2003.
5
Identification and expression of the genes encoding a reactivating factor for adenosylcobalamin-dependent glycerol dehydratase.腺苷钴胺素依赖性甘油脱水酶再激活因子编码基因的鉴定与表达
J Bacteriol. 1999 Jul;181(13):4110-3. doi: 10.1128/JB.181.13.4110-4113.1999.
6
In situ reactivation of glycerol-inactivated coenzyme B12-dependent enzymes, glycerol dehydratase and diol dehydratase.甘油失活的依赖辅酶B12的酶（甘油脱水酶和二醇脱水酶）的原位再激活。
J Bacteriol. 1980 Sep;143(3):1458-65. doi: 10.1128/jb.143.3.1458-1465.1980.
7
Optimizing aerobic conversion of glycerol to 3-hydroxypropionaldehyde.优化甘油向3-羟基丙醛的好氧转化。
Appl Environ Microbiol. 1985 Dec;50(6):1444-50. doi: 10.1128/aem.50.6.1444-1450.1985.