产气气杆菌中腺苷钴胺素依赖性甘油脱水酶的作用机制研究。II. 甘油脱水酶与腺苷钴胺素及其类似物复合物的失活动力学
Study of the mechanism of action of adenosylcobalamindependent glycerol dehydratase from Aerobacter aerogenes. II. The inactivation kinetics of glycerol dehydratase complexes with adenosylobalamin and its analogs.
作者信息
Poznanskaya A A, Yakusheva M I, Yakovlev V A
出版信息
Biochim Biophys Acta. 1977 Sep 15;484(1):236-43. doi: 10.1016/0005-2744(77)90128-0.
PMID:889846
Abstract
The inactivation kinetics of vacterial glycerol dehydratase (EC 4.2.1.30) in the course of its reaction with adenosylcobalamin (AdoCbl) and its analogs were investigated. It was shown that the inactivation rate of apoenzyme complexes with AdoCbl analogs is determined by the nature of the analogs employed and probably by the rate of their conversion into hydroxycobalamins. A possible inactivation mechanism of glycerol dehydratase is discussed.
摘要
研究了细菌甘油脱水酶（EC 4.2.1.30）在与腺苷钴胺素（AdoCbl）及其类似物反应过程中的失活动力学。结果表明，脱辅基酶与AdoCbl类似物复合物的失活速率取决于所用类似物的性质，可能还取决于它们转化为羟基钴胺素的速率。讨论了甘油脱水酶可能的失活机制。
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