非胰岛素依赖型糖尿病患者的血浆纤维蛋白原及其与血浆唾液酸的关系。

Plasma fibrinogen and its relationship to plasma sialic acid in non-insulin-dependent diabetes mellitus.

作者信息

Crook M A, Couchman S, Tutt P

机构信息

Guy's Hospital, London, UK.

出版信息

Blood Coagul Fibrinolysis. 1996 Sep;7(6):586-9. doi: 10.1097/00001721-199609000-00002.

DOI:10.1097/00001721-199609000-00002

PMID:8899146

Abstract

Serum or plasma sialic acid (SA) has been shown to be a possible risk factor for cardiovascular disease and to be elevated in diabetes mellitus. We postulated that plasma SA may be related to plasma fibrinogen, another reputed cardiovascular risk factor. We decided to test this hypothesis in 27 patients with non-insulin-dependent diabetes mellitus (NIDDM) and 27 age- and sex-matched control subjects. Plasma fibrinogen was significantly elevated in the diabetic patients compared with the control subjects (3.4 +/- 1.5 g/l versus 2.2 +/- 0.6 g/l, P < 0.001). Similarly, plasma SA was elevated in the diabetic patients in comparison with the control subjects (0.74 +/- 0.14 g/l versus 0.62 +/- 0.08 g/l, P < 0.001). There was a strong univariate correlation between plasma fibrinogen and plasma SA in both NIDDM patients (r = 0.80, P < 0.001) and control subjects (r = 0.54, P < 0.01).

摘要

血清或血浆唾液酸（SA）已被证明可能是心血管疾病的一个风险因素，并且在糖尿病患者中会升高。我们推测血浆SA可能与另一个公认的心血管风险因素——血浆纤维蛋白原有关。我们决定在27例非胰岛素依赖型糖尿病（NIDDM）患者和27例年龄及性别匹配的对照受试者中验证这一假设。与对照受试者相比，糖尿病患者的血浆纤维蛋白原显著升高（3.4±1.5 g/l对2.2±0.6 g/l，P<0.001）。同样，与对照受试者相比，糖尿病患者的血浆SA也升高（0.74±0.14 g/l对0.62±0.08 g/l，P<0.001）。在NIDDM患者（r = 0.80，P<0.001）和对照受试者（r = 0.54，P<0.01）中，血浆纤维蛋白原与血浆SA之间均存在很强的单变量相关性。