Beauparlant P, Hiscott J
Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec, Canada.
Cytokine Growth Factor Rev. 1996 Aug;7(2):175-90. doi: 10.1016/1359-6101(96)00020-2.
The NF-kappa B/Rel family of transcription factors participates in the activation of a diverse range of genes involved in inflammation, immune response, lymphoid differentiation, growth control and development. The present review provides a brief overview of NF-kappa B/Rel activation and a detailed analysis of important biological and biochemical inhibitors of the NF-kappa B/Rel pathway. Given the pleiotropic role of NF-kappa B in controlling cytokines and other immunoregulatory genes, the inhibition of NF-kappa B activation by steroid hormones, antioxidants, protease inhibitors and other compounds may provide a pharmacological basis for interfering with pathological inflammatory conditions, cancer and AIDS.
转录因子NF-κB/Rel家族参与激活多种与炎症、免疫反应、淋巴细胞分化、生长控制和发育相关的基因。本综述简要概述了NF-κB/Rel的激活，并详细分析了NF-κB/Rel信号通路重要的生物学和生化抑制剂。鉴于NF-κB在控制细胞因子和其他免疫调节基因方面具有多效性作用，类固醇激素、抗氧化剂、蛋白酶抑制剂和其他化合物对NF-κB激活的抑制作用可能为干预病理性炎症、癌症和艾滋病提供药理学依据。
