Matsuo M, Kataoka Y, Mataki S, Kato Y, Oi K
Department of Dental Anesthesiology, Nagasaki University Dental Hospital, Japan.
Neurosci Lett. 1996 Sep 13;215(3):197-200. doi: 10.1016/0304-3940(96)12982-7.
The release of serotonin (5-hydroxytryptamine, 5-HT) in the dorsal hippocampus was measured using an in vivo microdialysis method in rats subjected to the Vogel type conflict test. The conflict situation significantly increased 5-HT release in the dorsal hippocampus. Midazolam (0.75 and 1.5 mg/kg i.p.) suppressed the dosage-dependently this increased 5-HT release, an inhibition closely associated with the attenuation of conflict behavior. These findings suggest that the activation of serotonergic neuronal activity in the dorsal hippocampus is linked to mediation of anxiety-related behavior.
采用体内微透析法，在接受Vogel型冲突试验的大鼠中测量背侧海马体中5-羟色胺（5-羟色胺，5-HT）的释放。冲突情境显著增加了背侧海马体中5-HT的释放。咪达唑仑（腹腔注射0.75和1.5mg/kg）剂量依赖性地抑制了这种增加的5-HT释放，这种抑制与冲突行为的减弱密切相关。这些发现表明，背侧海马体中血清素能神经元活动的激活与焦虑相关行为的调节有关。
