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Cloning and nucleotide sequence of the mphB gene for macrolide 2'-phosphotransferase II in Escherichia coli.

作者信息

Noguchi N, Katayama J, O'Hara K

机构信息

Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan.

出版信息

FEMS Microbiol Lett. 1996 Nov 1;144(2-3):197-202. doi: 10.1111/j.1574-6968.1996.tb08530.x.

DOI:10.1111/j.1574-6968.1996.tb08530.x
PMID:8900063
Abstract

Macrolide 2'-phosphotransferase II [MPH(2')II] inactivates macrolide antibiotics. The mphB gene for MPH(2')II was cloned from Escherichia coli and sequenced. Analysis of the nucleotide sequence indicated that mphB encoded a protein of 302 amino acids with a molecular mass of 34483 Da. The carboxy terminal region of the deduced protein contained a sequence that resembled a conserved functional domain in aminoglycoside phosphotransferases.

摘要

相似文献

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Cloning and nucleotide sequence of the mphB gene for macrolide 2'-phosphotransferase II in Escherichia coli.
FEMS Microbiol Lett. 1996 Nov 1;144(2-3):197-202. doi: 10.1111/j.1574-6968.1996.tb08530.x.
2
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