Londesborough P, Ho L, Terry G, Cuzick J, Wheeler C, Singer A
Division of Pathology, University College London Medical School, UK.
Int J Cancer. 1996 Oct 21;69(5):364-8. doi: 10.1002/(SICI)1097-0215(19961021)69:5<364::AID-IJC2>3.0.CO;2-3.
Women referred for colposcopy with mild and moderate dyskaryosis and found to have only minor cervical abnormalities were screened for oncogenic human papilloma virus (HPV) types. The natural development of these abnormalities in 42 HPV-positive women was assessed by cytology and colposcopy at 6-month intervals for up to 2 years. As is the case with cancers and high-grade cervical intra-epithelial neoplasia (CIN), minor cervical abnormalities were frequently found to be associated with HPV16, -18, -31 and -33. Viral persistence and the development of high-grade lesions were found to be closely associated with HPV16; 56% of HPV16 isolates were persistent compared to 7% of other HPV types, and all 4 subsequent CIN 3 lesions were in women with persistent infection. A striking association of persistence with a variant of HPV16 having a base change at nucleotide 350 was observed. Ten of 12 women with this variant had persistent infection compared to only 1 of 16 women infected with the HPV16 prototype.
因轻度和中度核异质而转诊接受阴道镜检查且仅发现轻微宫颈异常的女性，接受了致癌性人乳头瘤病毒（HPV）分型检测。对42名HPV阳性女性这些异常情况的自然发展过程，通过细胞学和阴道镜检查进行评估，每隔6个月进行一次，为期长达2年。与癌症和高级别宫颈上皮内瘤变（CIN）的情况一样，经常发现轻微宫颈异常与HPV16、-18、-31和-33相关。发现病毒持续存在和高级别病变的发展与HPV16密切相关；56%的HPV16分离株持续存在，而其他HPV类型为7%，随后所有4例CIN 3病变均发生在持续感染的女性中。观察到持续存在与HPV16的一种在核苷酸350处有碱基变化的变体之间存在显著关联。12名携带此变体的女性中有10名持续感染，而感染HPV16原型的16名女性中只有1名持续感染。
