Mee J M, Korth J, Halpern B, James L B
Biomed Mass Spectrom. 1977 Jun;4(3):178-81. doi: 10.1002/bms.1200040310.
A quantitative analysis of amino acids in microsamples of dried blood spots by chemical ionization mass spectrometry has been developed. Isotope ratio determination was used as the quantitating technique via multiple labelled internal standards. This procedure yields excellent precision and accuracy as demonstrated by the analysis of known amino acid mixtures and of phenylalanine in the blood from newborns.
已开发出一种通过化学电离质谱法对干血斑微量样本中的氨基酸进行定量分析的方法。通过多个标记内标，将同位素比测定用作定量技术。如对已知氨基酸混合物以及新生儿血液中的苯丙氨酸进行分析所示，该程序具有出色的精密度和准确度。
