体内肉瘤180从实体瘤转变为腹水瘤过程中热休克蛋白47（HSP47）的抑制作用。
Inhibition of HSP47 during the transition from solid to ascitic form of Sarcoma 180 in vivo.
作者信息
Shirakami T, Tsuzuki T, Iijima H, Ishikawa Y, Kiyosuke Y I, Morino M, Yoshimura M, Yoshikumi C
机构信息
Kureha Chemical Industry Co., Ltd., Tokyo, Japan.
出版信息
In Vivo. 1995 Sep-Oct;9(5):509-12.
HSP47, a collagen-binding stress protein, has transformation-sensitivity; that is, the synthesis of HSP47 decreases after malignant transformation. We examined the expression of HSP47 in transplanted tumours by Western blotting. While HSP47 was not detected in ascites tumours including Ehrlich, P388 and Sarcoma 180, marked expression of HSP47 was observed in solid tumours such as B16, B16-BL6 and Sarcoma 180. The expression of HSP47 in Sarcoma 180 cells disappeared completely after these solid tumour cells were dispersed and inoculated intraperitoneally. These findings suggested an important role of HSP47 as a marker for tumour malignancy.
热休克蛋白47（HSP47）是一种胶原结合应激蛋白，具有转化敏感性；也就是说，恶性转化后HSP47的合成会减少。我们通过蛋白质免疫印迹法检测了移植瘤中HSP47的表达。在腹水瘤（包括艾氏腹水瘤、P388和肉瘤180）中未检测到HSP47，但在实体瘤（如B16、B16-BL6和肉瘤180）中观察到HSP47有明显表达。将肉瘤180实体瘤细胞分散并腹腔接种后，肉瘤180细胞中HSP47的表达完全消失。这些发现表明HSP47作为肿瘤恶性程度标志物具有重要作用。
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