热休克蛋白47作为体内肿瘤恶性程度的一种可能标志物。
HSP47 as a possible marker for malignancy of tumors in vivo.
作者信息
Morino M, Yasuda T, Shirakami T, Kiyosuke Y, Yoshimura M, Furusho T, Yoshikumi C
机构信息
Kureha Chemical Industry, Tokyo, Japan.
出版信息
In Vivo. 1994 May-Jun;8(3):285-8.
We have developed a rat monoclonal antibody against mouse HSP47 (designated as NK47) and investigated the expression of HSP47 in several mouse ascites and solid tumors. The expression of HSP47 was not detected in ascites tumors such as P388 and Ehrlich ascites tumors while HSP47 was markedly expressed in solid tumors such as Colon-26, B16 and B16-BL6 melanomas. HSP70, HSC70 and HSP90 were expressed in almost the same level among all the tumors examined. These results suggest that the expression of HSP47 decreases as the tumor becomes more malignant.
我们研发了一种针对小鼠热休克蛋白47（HSP47）的大鼠单克隆抗体（命名为NK47），并研究了HSP47在几种小鼠腹水瘤和实体瘤中的表达情况。在腹水瘤如P388和艾氏腹水瘤中未检测到HSP47的表达，而在实体瘤如结肠26、B16和B16 - BL6黑色素瘤中HSP47显著表达。在所检测的所有肿瘤中，HSP70、HSC70和HSP90的表达水平几乎相同。这些结果表明，随着肿瘤恶性程度增加，HSP47的表达会降低。
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