热休克蛋白47（HSP47）在高恶性小鼠纤维肉瘤中的表达降低。
Decreased expression of HSP47 in highly malignant mouse fibrosarcoma.
作者信息
Shirakami T, Tsuzuki T, Morino M, Kiyosuke Y I, Yoshimura M, Yoshikumi C, Okada F, Hosokawa M
机构信息
Senior Research Fellow Laboratory, Kureha Chemical Industry, Co., Ltd., Tokyo, Japan.
出版信息
In Vivo. 1995 Sep-Oct;9(5):513-8.
HSP47, a heat shock-inducible glycoprotein of M(r) = 47,000, is assumed to be a molecular chaperone specific for collagen. In addition to its stress inducibility, HSP47 has transformation-sensitivity; that is, the synthesis of HSP47 decreases after malignant transformation. The expression of several HSPs in mouse fibrosarcoma, QRsP-1 and QRsP-4 were examined. HSP47 expression was weaker in the highly malignant QRsP-4 than in the weakly malignant QRsP-1, whilst HSC70 expression was similar in both cell lines. These findings suggested an important role of HSP47 as a marker of tumour malignancy of QRsP cell lines.
HSP47是一种分子量为47000的热休克诱导糖蛋白，被认为是胶原蛋白特异性的分子伴侣。除了应激诱导性外，HSP47还具有转化敏感性；也就是说，恶性转化后HSP47的合成会减少。检测了小鼠纤维肉瘤QRsP-1和QRsP-4中几种热休克蛋白的表达。高度恶性的QRsP-4中HSP47的表达比低度恶性的QRsP-1弱，而两种细胞系中HSC70的表达相似。这些发现表明HSP47作为QRsP细胞系肿瘤恶性程度标志物具有重要作用。
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