Decreased expression of HSP47 in highly malignant mouse fibrosarcoma. - Suppr | 超能文献

Decreased expression of HSP47 in highly malignant mouse fibrosarcoma.

作者信息

Shirakami T, Tsuzuki T, Morino M, Kiyosuke Y I, Yoshimura M, Yoshikumi C, Okada F, Hosokawa M

机构信息

Senior Research Fellow Laboratory, Kureha Chemical Industry, Co., Ltd., Tokyo, Japan.

出版信息

In Vivo. 1995 Sep-Oct;9(5):513-8.

Abstract

HSP47, a heat shock-inducible glycoprotein of M(r) = 47,000, is assumed to be a molecular chaperone specific for collagen. In addition to its stress inducibility, HSP47 has transformation-sensitivity; that is, the synthesis of HSP47 decreases after malignant transformation. The expression of several HSPs in mouse fibrosarcoma, QRsP-1 and QRsP-4 were examined. HSP47 expression was weaker in the highly malignant QRsP-4 than in the weakly malignant QRsP-1, whilst HSC70 expression was similar in both cell lines. These findings suggested an important role of HSP47 as a marker of tumour malignancy of QRsP cell lines.

摘要

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