Cadherin cell adhesion molecules in differentiation and embryogenesis.

The cadherin gene superfamily of calcium-dependent cell-cell adhesion molecules contains more than 40 members. We summarize functions attributed to these proteins, especially their roles in cellular differentiation and embryogenesis. We also describe hierarchies of protein-protein interactions between cadherins and cadherin-associated proteins (catenins). Several signal transduction pathways converge on, and diverge from, the cadherin/catenin complex to regulate its function; we speculate on roles of these signaling processes for cell structure and function. This review provides a framework for interpretation of developmental functions of cadherin cell adhesion molecules.