Gunnell D J, Frankel S, Nanchahal K, Braddon F E, Smith G D
Department of Social Medicine, University of Bristol.
Public Health. 1996 Mar;110(2):85-94. doi: 10.1016/s0033-3506(96)80052-7.
There is an increasing interest in the origins of adult disease in early life. The elucidation of such explanations of current morbidity and mortality must depend upon the follow-up of previously established cohorts. This paper describes the design of and background to such a follow-up of one of the richest data sources for this type of research: Sir John Boyd Orr's survey of diet and health in pre-war Britain. 1,352 families from 16 centres in England and Scotland were surveyed; 3,762 children aged up to 19 years from these families were examined. Socio-economic information and detailed one week dietary diary records are available for all families. Detailed medical examinations (including anthropometry) were undertaken on children in 14 of the centres. Most of the information is cross-sectional although 1,322 children were examined on two or more occasions one year apart to assess the effects of dietary supplementation. Dietary records were retrieved for 1,343 (99.3%) of the families. Medical examination records were found for 3,560 (94.6%) of the children who were examined in the survey and attempts have been made to trace 4,973 children who were either examined or whose family participated in the dietary survey. The data demonstrate relationships between family food expenditure and height in childhood and housing conditions. Eighty-five per cent (4211/4973) of the children have been traced and flagged on the National Health Service Central Register, Southport. The characteristics of those traced do not differ significantly from those we have been unable to trace although untraced females were slightly heavier. To date 696 (16.5%) of the cohort have died. The cohort will be used to investigate the relationship between diet, nutritional status (height, weight, cristal height), health and social circumstances in childhood, and mortality and morbidity in adulthood.
人们对成人疾病的早期起源越来越感兴趣。要阐明当前发病率和死亡率的此类原因，必须依赖对先前建立的队列进行随访。本文描述了此类随访的设计和背景，该随访基于这类研究最丰富的数据源之一：约翰·博伊德·奥尔爵士对战前英国饮食与健康的调查。对来自英格兰和苏格兰16个中心的1352个家庭进行了调查；对这些家庭中3762名19岁及以下的儿童进行了检查。所有家庭都有社会经济信息和详细的一周饮食日记记录。对14个中心的儿童进行了详细的医学检查（包括人体测量）。尽管对1322名儿童进行了一年一次或多次的检查以评估膳食补充剂的效果，但大多数信息是横断面的。检索到了1343个（99.3%）家庭的饮食记录。在调查中接受检查的儿童中，找到了3560个（94.6%）儿童的医学检查记录，并试图追踪4973名接受过检查或其家庭参与了饮食调查的儿童。数据表明家庭食品支出与儿童身高和住房条件之间的关系。85%（4211/4973）的儿童已在南港的国民健康服务中央登记处被追踪并标记。已追踪到的儿童的特征与我们未能追踪到的儿童没有显著差异，尽管未被追踪到的女性体重略重。迄今为止，该队列中有696人（16.5%）死亡。该队列将用于研究儿童时期的饮食、营养状况（身高、体重、晶体高度）、健康和社会环境与成年期死亡率和发病率之间的关系。
