博伊德·奥尔队列研究中的可重复性测量及其对饮食与癌症关联的影响。

Reproducibility measures and their effect on diet-cancer associations in the Boyd Orr cohort.

作者信息

Frobisher Clare, Tilling Kate, Emmett Pauline M, Maynard Maria, Ness Andrew R, Davey Smith George, Frankel Stephen J, Gunnell David J

机构信息

Department of Public Health and Epidemiology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

出版信息

J Epidemiol Community Health. 2007 May;61(5):434-40. doi: 10.1136/jech.2006.046524.

DOI:10.1136/jech.2006.046524

PMID:17435211

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2465690/

Abstract

OBJECTIVES

To quantify measurement error in the estimation of family diet intakes using 7-day household food inventories and to investigate the effect of measurement-error adjustment on diet-disease associations.

DESIGN AND SETTING

Historical cohort study in 16 districts in England and Scotland, between 1937 and 1939.

SUBJECTS

4999 children from 1352 families in the Carnegie Survey of Diet and Health. 86.6% of these children were traced as adults and form the Boyd Orr cohort. The reproducibility analysis was based on 195 families with two assessments of family diet recorded 3-15 months apart.

METHODS

Intraclass correlation coefficients (ICCs) were calculated for a variety of nutrients and food groups. Diet-cancer associations reported previously in the Boyd Orr cohort were reassessed using two methods: (a) the ICC and (b) the regression calibration.

MAIN RESULTS

The ICCs for the dietary intakes ranged from 0.44 (beta carotene) to 0.85 (milk and milk products). The crude fully adjusted hazard ratio (HR) for cancer mortality per 1 MJ/day increase in energy intake was 1.15 (95% CI 1.06 to 1.24). After adjustment using the ICC for energy (0.80) the HR (95% CI) increased to 1.19 (1.08 to 1.31), and the estimate from regression calibration was 1.14 (0.98 to 1.32). The crude fully adjusted odds ratio (OR) for cancer incidence per 40 g/day increase in fruit intake was 0.84 (95% CI 0.73 to 0.97). After adjustment using the fruit ICC (0.78) it became 0.81 (0.67 to 0.96) and the OR derived from regression calibration was 0.81 (0.59 to 1.10).

CONCLUSIONS

The diet-disease relationships for the dietary intakes with low measurement error were robust to adjustment for measurement error.

摘要

目的

使用7天家庭食物清单来量化家庭饮食摄入量估计中的测量误差，并研究测量误差调整对饮食与疾病关联的影响。

设计与背景

1937年至1939年间在英格兰和苏格兰16个地区进行的历史性队列研究。

研究对象

卡内基饮食与健康调查中1352个家庭的4999名儿童。这些儿童中有86.6%在成年后被追踪到，并构成了博伊德·奥尔队列。重复性分析基于195个家庭，对家庭饮食进行了两次评估，记录时间相隔3至15个月。

方法

计算了多种营养素和食物组的组内相关系数（ICC）。使用两种方法重新评估了博伊德·奥尔队列先前报告的饮食与癌症关联：（a）ICC和（b）回归校准。

主要结果

饮食摄入量的ICC范围从0.44（β-胡萝卜素）到0.85（牛奶及奶制品）。能量摄入量每增加1兆焦耳/天，癌症死亡率的粗完全调整风险比（HR）为1.15（95%置信区间1.06至1.24）。使用能量的ICC（0.80）进行调整后，HR（95%置信区间）增至1.19（1.08至1.31），回归校准的估计值为1.14（0.98至1.32）。水果摄入量每增加40克/天，癌症发病率的粗完全调整比值比（OR）为0.84（95%置信区间0.73至0.97）。使用水果的ICC（0.78）进行调整后，变为0.81（0.67至0.96），回归校准得出的OR为0.81（0.59至1.10）。