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[不同类型结缔组织对激素给药的反应]

[Responses of different types of connective tissue to hormone administration].

作者信息

Kasavina B S, Torbenko V P, Ukhina T V

出版信息

Biull Eksp Biol Med. 1977 Jul;84(7):38-41.

PMID:890133
Abstract

The lysosomal glycosidase activity of the eye tissues (the sclera and cornea), the bone tissues and cartilage were studied. The intraperitoneal injection of tyrocalcitonine (TCT), deoxycorticosterone (DOCS), hydrocortisone (HC), and somatotropic hormone (STH) influenced both the activity of beta-galactosidase, beta-glucosidase, and hyaluronidase, the the functional state of thy lysosomal membranes of the connective tissues under investigation. GC and STH caused stabilization, whereas DOCS and large doses of TCT--a labilizing effect on the lysosomal membranes and tissues understudy. The absolute activity of the enzymes in the homogenates decreased after the HC and STH injection. DOCS produced an opposite effect.

摘要

研究了眼组织(巩膜和角膜)、骨组织和软骨的溶酶体糖苷酶活性。腹腔注射酪氨酸降钙素(TCT)、脱氧皮质酮(DOCS)、氢化可的松(HC)和生长激素(STH),对β-半乳糖苷酶、β-葡萄糖苷酶和透明质酸酶的活性以及所研究结缔组织溶酶体膜的功能状态均有影响。糖皮质激素(GC)和生长激素(STH)可使其稳定,而脱氧皮质酮(DOCS)和大剂量的酪氨酸降钙素(TCT)则对所研究的溶酶体膜和组织产生不稳定作用。注射氢化可的松(HC)和生长激素(STH)后,匀浆中酶的绝对活性降低。脱氧皮质酮(DOCS)则产生相反的效果。

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