Pelzer T, Shamim A, Neyses L
Department of Medicine, University of Würzburg, Germany.
Mol Cell Biochem. 1996 Jul-Aug;160-161:307-13. doi: 10.1007/BF00240064.
Gender specific differences in cardiovascular disease are largely mediated by sex hormones. The use of estrogens significantly reduces the overall incidence of heart disease in postmenopausal women. Beneficial effects of estrogens on plasma lipoprotein levels are clearly established. However, these do not explain the magnitude of risk reduction seen in clinical studies. Thus additional and currently unknown functions of estrogens must be operative. Elucidation of the exact estrogen action in the heart will have important implications in the treatment of cardiovascular disease. It will probably enhance the therapeutic repertoire in treating heart disease, the most common cause of death in industrialized countries. We will review the current understanding of the function of estrogens in the heart and discuss potential strategies on how to apply these data to clinical practice.
心血管疾病中的性别特异性差异很大程度上由性激素介导。雌激素的使用显著降低了绝经后女性心脏病的总体发病率。雌激素对血浆脂蛋白水平的有益作用已得到明确证实。然而，这些并不能解释临床研究中所观察到的风险降低幅度。因此，雌激素必定还有其他目前未知的作用在发挥功效。阐明雌激素在心脏中的具体作用机制对于心血管疾病的治疗具有重要意义。这可能会增加治疗心脏病的方法，心脏病是工业化国家最常见的死亡原因。我们将综述目前对雌激素在心脏中功能的认识，并讨论如何将这些数据应用于临床实践的潜在策略。
