Kuiper G G, Gustafsson J A
Center for Biotechnology and Department of Medical Nutrition, Karolinska Institute, NOVUM, Huddinge, Sweden.
FEBS Lett. 1997 Jun 23;410(1):87-90. doi: 10.1016/s0014-5793(97)00413-4.
The recent discovery that an additional estrogen receptor (ER) subtype is present in various rat, mouse and human tissues has advanced our understanding of the mechanisms underlying estrogen signalling. The discovery of a second ER subtype (ERbeta) suggests the existence of two previously unrecognised pathways of estrogen signalling: via the ERbeta subtype in tissues exclusively expressing this subtype and via the formation of heterodimers in tissues expressing both ER subtypes. Various models have been suggested as explanations for the striking cell- and promoter-specific effects of estrogens and anti-estrogens, all on the basis of the assumption that only a single ER gene exists. This minireview describes several of these models and focuses on the potential role which the novel ERbeta subtype might have in this regard.
最近发现，在各种大鼠、小鼠和人体组织中存在一种额外的雌激素受体（ER）亚型，这增进了我们对雌激素信号传导潜在机制的理解。第二种ER亚型（ERβ）的发现表明存在两条以前未被认识的雌激素信号传导途径：一条是通过仅表达该亚型的组织中的ERβ亚型，另一条是通过在同时表达两种ER亚型的组织中形成异二聚体。人们提出了各种模型来解释雌激素和抗雌激素显著的细胞和启动子特异性效应，所有这些模型都是基于仅存在单一ER基因这一假设。这篇小型综述描述了其中的几种模型，并重点关注新型ERβ亚型在这方面可能具有的潜在作用。
