Masucci J P, Schon E A
Department of Genetics and Development, Columbia University, New York, NY 10032, USA.
Mol Biol Rep. 1995;22(2-3):187-93. doi: 10.1007/BF00988727.
Many human mitochondrial disorders are associated with mutations in tRNA genes or with deletions of regions containing tRNA genes, all of which may be suspected to play a role in recognition by RNase P. Here we describe the analysis of five such mutations. The results presented here demonstrate that none of these mutations result in errors in RNase P function. Further studies of mutations in tRNAs need to be pursued to elucidate the identity elements for RNase P function in mammalian mitochondria.
许多人类线粒体疾病与tRNA基因的突变或包含tRNA基因区域的缺失有关，所有这些都可能被怀疑在核糖核酸酶P的识别中起作用。在此，我们描述了对五个此类突变的分析。此处呈现的结果表明，这些突变均未导致核糖核酸酶P功能出现差错。需要对tRNA中的突变进行进一步研究，以阐明哺乳动物线粒体中核糖核酸酶P功能的识别元件。
