Scheidegger C, Zimmerli W
Department of Internal Medicine, University Hospital of Basel, Switzerland.
AIDS. 1996 Oct;10(12):1407-14. doi: 10.1097/00002030-199610000-00014.
To examine differences in the incidence and spectrum of diseases, as well as duration of inpatient stay, between HIV-seronegative and HIV-seropositive narcotic drug, users (NDU).
Retrospective analysis of 9 years of experience. Data collection by chart review using preset criteria for diagnoses. Estimation of hospital admission densities by assuming a dynamic but stable population of 2000 NDU (with a mean HIV-seroprevalence of 25%) throughout the study period.
Comprising 314 HIV-seronegative NDU. 217 HIV-seropositive NDU, and 10 NDU with admissions registered in either group (from a total of 1011 admissions).
The overall admission incidence density was 35 and 120 per 1000 person-years among HIV-seronegative NDU and HIV-seropositive NDU, respectively [risk ratio (RR) 3.5, 95% confidence interval (CI) 3.2-3.7]. Compared with seronegative NDU, HIV-seropositive NDU were more frequently admitted for various non-opportunistic infections (RR 7.2, 95% CI 6.1-8.4), including pneumonia (RR 10.9, 95% CI 7.6-16.6), tuberculosis (RR 30.0, 95% CI 3.6-233.8), soft-tissue infections (RR 3.5, 95% CI 1.7-7.2), osteoarticular infections (RR 6.0, 95% CI 1.5-23.9), endocarditis (RR 5.3, 95% CI 1.5-17.9), and various other infections (RR 5.8, 95% CI 3.2-10.5). HIV-seropositive NDU were also more frequently admitted for non-infectious medical complications (RR 2.3, 95% CI 1.8-3.0). Seronegative NDU had a shorter median inpatient stay (2 versus 9 days, P < 0.00001). HIV infection accounted for an estimated excess burden of at least 2700 inpatient care days in 9 years among the 500 local HIV-seropositive NDU.
Among NDU, HIV infection adds considerable excess burden in terms of severe complications needing inpatient care.
研究HIV血清学阴性和血清学阳性的麻醉药品使用者（NDU）之间疾病发病率、疾病谱以及住院时间的差异。
对9年经验的回顾性分析。通过病历审查，依据预设的诊断标准收集数据。假设在整个研究期间有2000名动态但稳定的NDU人群（平均HIV血清阳性率为25%），估算住院入院密度。
包括314名HIV血清学阴性的NDU、217名HIV血清学阳性的NDU，以及在两组中均有入院记录的10名NDU（共1011次入院）。
HIV血清学阴性的NDU和HIV血清学阳性的NDU的总体入院发病率密度分别为每1000人年35次和120次[风险比（RR）3.5，95%置信区间（CI）3.2 - 3.7]。与血清学阴性的NDU相比，HIV血清学阳性的NDU因各种非机会性感染入院的频率更高（RR 7.2，95% CI 6.1 - 8.4），包括肺炎（RR 10.9，95% CI 7.6 - 16.6）、结核病（RR 30.0，95% CI 3.6 - 233.8）、软组织感染（RR 3.5，95% CI 1.7 - 7.2）、骨关节炎感染（RR 6.0，95% CI 1.5 - 23.9）、心内膜炎（RR 5.3，95% CI 1.5 - 17.9）以及各种其他感染（RR 5.8，95% CI 3.2 - 10.5）。HIV血清学阳性的NDU因非感染性医疗并发症入院的频率也更高（RR 2.3，95% CI 1.8 - 3.0）。血清学阴性的NDU中位住院时间较短（2天对9天，P < 0.00001）。在当地500名HIV血清学阳性的NDU中，估计9年内HIV感染导致至少2700个住院护理日的额外负担。
在NDU中，HIV感染在需要住院护理的严重并发症方面增加了相当大的额外负担。
