Srikiatkhachorn A, Anthony M
Institute of Neurological Sciences, Prince Henry and Prince of Wales Hospitals and School of Medicine, University of New South Wales, Sydney, Australia.
Cephalalgia. 1996 Oct;16(6):423-6. doi: 10.1046/j.1468-2982.1996.1606423.x.
The purpose of this study was to investigate the role of serotonin (5HT) in patients with analgesic-induced headache (AIH). We estimated platelet 5HT concentration in patients with AIH, migraine patients and non-headache controls, by using high performance liquid chromatography with electrochemical detection. Our results revealed a significant decrease (p < 0.001) in platelet 5HT content in patients with AIH as compared to migraine patients and non-headache controls (221.8 +/- 30.7, 445.3 +/- 37.4 and 467.2 +/- 38.5 ng/10(9) platelets, respectively). In contrast, a difference of lesser statistical significance (p = 0.022) was observed in platelet 5HT content after incubation with excess 5HT (1940.0 +/- 195.1, 2610.0 +/- 173.1 and 2560 +/- 165.2 ng/10(9) platelets for patients with AIH, migraine patients and non-headache controls, respectively). These data suggest that analgesic-induced suppression of 5HT uptake may interfere with the function of the pain modulatory system in the brainstem. Although the process by which analgesics interfere with this system is as yet unknown, it is possible that it may not be entirely due to defective 5HT uptake mechanisms.
本研究的目的是调查血清素（5HT）在镇痛剂诱发头痛（AIH）患者中的作用。我们通过使用高效液相色谱电化学检测法，估计了AIH患者、偏头痛患者和无头痛对照组的血小板5HT浓度。我们的结果显示，与偏头痛患者和无头痛对照组相比，AIH患者的血小板5HT含量显著降低（p < 0.001）（分别为221.8 +/- 30.7、445.3 +/- 37.4和467.2 +/- 38.5 ng/10(9)个血小板）。相比之下，在与过量5HT孵育后，血小板5HT含量的统计学差异较小（p = 0.022）（AIH患者、偏头痛患者和无头痛对照组分别为1940.0 +/- 195.1、2610.0 +/- 173.1和2560 +/- 165.2 ng/10(9)个血小板）。这些数据表明，镇痛剂诱发的5HT摄取抑制可能会干扰脑干中疼痛调节系统的功能。尽管镇痛剂干扰该系统的过程尚不清楚，但有可能并不完全是由于5HT摄取机制缺陷所致。
