药物性头痛偏头痛患者中的5-羟色胺

5HT in migraine patients with medication-induced headache.

作者信息

Hering R, Glover V, Pattichis K, Catarci T, Steiner T J

机构信息

Princess Margaret Migraine Clinic, Charing Cross Hospital, London, UK.

出版信息

Cephalalgia. 1993 Dec;13(6):410-2. doi: 10.1046/j.1468-2982.1993.1306410.x.

DOI:10.1046/j.1468-2982.1993.1306410.x

PMID:8313455

Abstract

Whole blood 5HT levels were measured in seven female migraine sufferers with chronic daily headache due to medication abuse, before and after abrupt medication withdrawal. A statistically significant increase in 5HT levels, from mean 4.89 mumol/l to mean 6.59 mumol/l (p < 0.05, Wilcoxon signed rank test), occurred after 4 weeks of withdrawal. We conclude from this pilot study that 5HT may be important in the physiopathogenesis of chronic daily headache. Alternatively, reduced 5HT may be the result of chronic daily headache or else an epiphenomenon.

摘要

对7名因药物滥用导致慢性每日头痛的女性偏头痛患者，在突然停药前后测量了全血5-羟色胺（5HT）水平。停药4周后，5HT水平出现了统计学上的显著升高，从平均4.89微摩尔/升升至平均6.59微摩尔/升（p<0.05，Wilcoxon符号秩检验）。我们从这项初步研究得出结论，5HT可能在慢性每日头痛的生理病理发生过程中起重要作用。或者，5HT降低可能是慢性每日头痛的结果，抑或是一种附带现象。