Drew P A, Furman J, Civantos F, Murphy W M
Department of Pathology and Laboratory Medicine, University of Florida College of Medicine, Gainesville 32610, USA.
Mod Pathol. 1996 Oct;9(10):989-94.
The nested variant of transitional cell carcinoma (TCC-NV) is a rare neoplasm; only eight cases have been described. This report reviews the clinicopathologic features of 16 additional examples. The cases were collected from consultations received during a 13-year period. In most instances, a consultation was sought because the histologic features suggested an atypical proliferation of Brunn's nests or a lesion similar to the previously published examples of TCC-NV. Clinical data were gathered and tissues were studied to exclude prostatic cancer and adenocarcinoma. TCC-NV is characterized by the presence of irregular nests and/or tubules of transitional cells infiltrating the lamina propria without surface involvement. Neoplastic cells tend to have innocuous features but at least a few cells in every case are cytologically anaplastic. There is a marked male predominance. Synchronous or metachronous TCCs of more usual histologic make-up may occur. After a follow-up averaging 16.6 months, only three patients are known to be alive with no evidence of disease. Clinicopathologic information from our 16 cases combined with the 8 previously reported examples confirms that TCC-NV is a persistent and aggressive neoplasm notable for its innocuous appearance in histologic preparations.
移行细胞癌巢状变异型（TCC-NV）是一种罕见的肿瘤；仅8例有过描述。本报告回顾了另外16例的临床病理特征。这些病例是从13年期间收到的会诊病例中收集的。在大多数情况下，进行会诊是因为组织学特征提示布伦巢（Brunn's nests）非典型增生或类似先前发表的TCC-NV病例的病变。收集了临床资料并对组织进行研究以排除前列腺癌和腺癌。TCC-NV的特征是存在不规则的移行细胞巢和/或小管浸润固有层而不累及表面。肿瘤细胞往往具有无害的特征，但每例中至少有一些细胞在细胞学上是间变的。男性明显占优势。可能会出现组织学构成更常见的同步或异时性移行细胞癌。平均随访16.6个月后，已知仅3例患者存活且无疾病证据。我们16例的临床病理信息与先前报告的8例相结合，证实TCC-NV是一种持续且侵袭性的肿瘤，在组织学切片中其外观无害是其显著特点。
