Aguilera N S, Howard L N, Brissette M D, Abbondanzo S L
Department of Hematologic and Lymphatic Pathology, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000, USA.
Mod Pathol. 1996 Oct;9(10):1020-6.
We describe a 74-year-old man who presented with multifocal small bowel lesions, a large mesenteric mass, and enlarged mesenteric lymph nodes. In each of the extranodal sites and in two of three regional lymph nodes, there were classic histologic features of marginal zone B-cell lymphoma with adjacent areas of Hodgkin's disease, mixed cellularity subtype. Immunophenotypic analysis in the areas of low-grade B-cell lymphoma of mucosa-associated lymphoid tissue showed immunoreactivity for CD45RB and CD20 in the malignant small cell population. Conversely, the areas of Hodgkin's disease demonstrated positive immunoreactivity for CD15 and CD30 in the Reed-Sternberg cells and variants. Latent membrane protein for Epstein-Barr virus was also positive in the Reed-Sternberg cells and variants.
我们描述了一名74岁男性，其表现为多灶性小肠病变、一个大的肠系膜肿块以及肠系膜淋巴结肿大。在每个结外部位以及三个区域淋巴结中的两个，均有边缘区B细胞淋巴瘤的典型组织学特征，伴有霍奇金病混合细胞型亚型的相邻区域。在黏膜相关淋巴组织的低级别B细胞淋巴瘤区域进行免疫表型分析显示，恶性小细胞群体中CD45RB和CD20呈免疫反应性。相反，霍奇金病区域在里德-斯腾伯格细胞及其变异体中CD15和CD30呈阳性免疫反应性。爱泼斯坦-巴尔病毒的潜伏膜蛋白在里德-斯腾伯格细胞及其变异体中也呈阳性。
