Jókay I, Karczag E, Kelemenics K, Földes I
Endokrinologie. 1979 Apr;73(2):199-208.
A single dose of heparin applied in a depot-form (Freund's incomplete adjuvant or Ca-phosphate gel) inhibits the effects of intraperitoneally injected cortisone on the lymphoid organs (thymus and spleen), on the peritoneal and peripheral lymphoid cell count and serum gamma globulin level as well as on the liver glycogen deposition in mice. The same dose of heparin did not influence the action of hydrocortisone measured on the thymic and spleen involution and liver glycogen content. The route of cortisone administration seems to be critical, as heparin shows no or only minor effects when cortisone is applied subcutaneously; moreover, the action of cortisone per se is more marked by subcutaneous than by intraperitoneal administration. The results suggest the hypothesis that heparin inhibits cortisone-cortisol conversion and this inhibition is mediated by macrophages.
以储存形式（弗氏不完全佐剂或磷酸钙凝胶）给予的单剂量肝素可抑制腹腔注射可的松对小鼠淋巴器官（胸腺和脾脏）、腹腔和外周淋巴细胞计数、血清γ球蛋白水平以及肝脏糖原沉积的影响。相同剂量的肝素对氢化可的松作用于胸腺和脾脏退化及肝脏糖原含量无影响。可的松的给药途径似乎至关重要，因为当皮下注射可的松时，肝素无作用或仅有轻微作用；此外，可的松本身皮下给药比腹腔给药的作用更显著。结果提示了一个假说，即肝素抑制可的松 - 皮质醇转化，且这种抑制由巨噬细胞介导。
