Loudon N B, Foxwell M, Potts D M, Guild A L, Short R V
Br Med J. 1977 Aug 20;2(6085):487-90. doi: 10.1136/bmj.2.6085.487.
The frequency of menstruation was reduced to once every three months in 196 women by the continuous administration of the oral contraceptive pill, Minilyn, for 84 days (tri-cycle regimen). No pregnancies occurred. One hundred and sixty-one women (82%) welcomed the reduction in the number of periods with the associated freedom from menstrual and premenstrual symptoms, and many found the tri-cycle regimen easier to follow. Weight gain of more than 2 kg, irregular cycle control, especially in the first three months, breast tenderness, and headaches were the main side effects. Menstrual loss was unchanged or reduced in all but seven women. The doctors and nurses on the clinic staff were less enthusiastic about this regimen than the volunteers themselves.
通过连续84天服用口服避孕药米妮琳（三周期方案），196名女性的月经频率降至每三个月一次。无一例怀孕。161名女性（82%）对月经次数减少以及随之而来的无月经和经前症状表示满意，许多人发现三周期方案更容易遵循。体重增加超过2公斤、月经周期控制不规律（尤其是在前三个月）、乳房胀痛和头痛是主要副作用。除7名女性外，所有女性的月经量均未改变或减少。诊所工作人员中的医生和护士对该方案的热情不如志愿者本人。
