Augusto V M, de Sousa A S, Moll R J, Duarte J G, Zin W A
Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brazil.
Respir Physiol. 1995 Dec;102(2-3):217-24. doi: 10.1016/0034-5687(95)00054-2.
Respiratory mechanics and thoraco-abdominal morphometry were evaluated in anesthetized, paralyzed, mechanically ventilated rats before and after controlled intraperitoneal injection of warm (37 degrees C) saline. Respiratory system resistances and static elastance were determined in 9 animals using the end inflation occlusion method. Chest wall configuration at both functional residual capacity (FRC) and end inspiration (FRC + VT) was evaluated in: (a) 6 rats by measurements of lateral and anteroposterior diameters, and circumferences at four levels: 3rd intercostal space, xiphoid, subcostal plane and crista iliaca; and (b) 8 rats by measurements of thoracic cephalo-caudal diameter. In addition, FRC changes were measured in 6 rats. Resistances were not altered but static elastance increased progressively. Morphometric changes were similar at both FRC and FRC + VT: cephalo-caudal diameter diminished whereas all other diameters augmented; FRC decreased. In conclusion, intraperitoneal infusion of saline in rats augments elastance, and this is related to a cephalad deviation of the diaphragm plus an increase of the circumferences and diameters of the lower thorax.
在对麻醉、麻痹并接受机械通气的大鼠进行腹腔内注射37摄氏度温盐水前后，评估其呼吸力学和胸腹形态测量学指标。使用终末充气阻断法在9只动物中测定呼吸系统阻力和静态弹性。在以下情况下评估功能残气量（FRC）和吸气末（FRC + VT）时的胸壁形态：（a）对6只大鼠，通过测量三个肋间平面、剑突、肋下平面和髂嵴四个水平的左右径、前后径和周长；（b）对8只大鼠，通过测量胸段头-尾径。此外，在6只大鼠中测量FRC变化。阻力未改变，但静态弹性逐渐增加。FRC和FRC + VT时的形态测量变化相似：头-尾径减小，而所有其他径线增大；FRC降低。总之，大鼠腹腔内输注盐水会增加弹性，这与膈肌头侧偏移以及下胸部周长和径线增加有关。
