Moll R J, Sousa A S, Pontes C F, Zin W A
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brasil.
Braz J Med Biol Res. 1995 Oct;28(10):1113-6.
The purpose of the present study was to determine the mechanical respiratory profile after the insertion of a catheter into the pleural cavity of anesthetized, paralyzed, mechanically ventilated rats, thus stimulating the common use of chest tubes in clinical situations. Using the method of end-inflation occlusion during constant inspiratory flow in 7 adult Wistar rats, respiratory system, lung, and chest wall total resistance (0.353 +/- 0.058, 0.260 +/- 0.651, 0.091 +/- 0.012 (mean +/- SD) cmH2O.ml-1.s, respectively), viscous resistance (0.140 +/- 0.007, 0.100 +/- 0.007, 0.040 +/- 0.003 cmH2O.ml-1.s< respectively), and viscoelastic resistance (0.213 +/- 0.017, 0.160 +/- 0.022, 0.053 +/- 0.011 cmH2O.ml-1.s, respectively) as well as respiratory system, lung, and chest wall static elastance (4.51 +/- 0.27, 3.85 +/- 0.28, 0.66 +/- 0.12 cmH2O.ml-1, respectively), and dynamic elastance (5.72 +/- 0.24, 4.76 +/- 0.32, 0.96 +/- 0.17 cmH2O.ml-1, respectively) were not significantly modified after the insertion of a tube into the second right intercostal stage. We conclude that, under the present experimental conditions, a catheter inserted into the pleural space per se is not responsible for any alterations in respiratory mechanics.
本研究的目的是确定在麻醉、麻痹、机械通气的大鼠胸腔内插入导管后的机械呼吸曲线，从而推动胸管在临床中的广泛应用。对7只成年Wistar大鼠在恒定吸气流量下采用终末充气阻断法，在右第二肋间置入导管后，呼吸系统、肺和胸壁的总阻力（分别为0.353±0.058、0.260±0.651、0.091±0.012（平均值±标准差）cmH₂O·ml⁻¹·s）、粘性阻力（分别为0.140±0.007、0.100±0.007、0.040±0.003 cmH₂O·ml⁻¹·s）、粘弹性阻力（分别为0.213±0.017、0.160±0.022、0.053±0.011 cmH₂O·ml⁻¹·s）以及呼吸系统、肺和胸壁的静态弹性（分别为4.51±0.27、3.85±0.28、0.66±0.12 cmH₂O·ml⁻¹）和动态弹性（分别为5.72±0.24、4.76±0.32、0.96±0.17 cmH₂O·ml⁻¹）均未发生显著改变。我们得出结论，在当前实验条件下，插入胸腔的导管本身不会导致呼吸力学的任何改变。
