Maquet P
Centre de recherches du cyclotron et service de neurologie du CHU Sart Tilman, Liege, Belgique.
Neurophysiol Clin. 1995;25(6):342-50. doi: 10.1016/0987-7053(96)84907-0.
Positron emission tomography (PET) allows the exploration of cerebral physiological and biochemical processes in vivo in man. Sleep studies using this technique first demonstrated that cerebral metabolic rates for glucose decrease during slow wave sleep in comparison with wakefulness whereas, during paradoxical sleep, the cerebral glucose metabolism is as high as during wakefulness. At present, several laboratories are currently exploring the regional modifications of cerebral blood flow during sleep. The results are partial and preliminary but seem to show a relative decrease in frontal cortex blood flow during slow sleep. This short review also considers some PET studies of sleep deprivation and sleep related pathologies.
正电子发射断层扫描（PET）能够在人体活体中探索大脑的生理和生化过程。利用这项技术进行的睡眠研究首次表明，与清醒状态相比，慢波睡眠期间大脑葡萄糖代谢率会降低，而在快速眼动睡眠期间，大脑葡萄糖代谢与清醒时一样高。目前，几个实验室正在探索睡眠期间大脑血流的区域变化。结果尚不完整且初步，但似乎显示慢波睡眠期间额叶皮质血流相对减少。这篇简短综述还考虑了一些关于睡眠剥夺和睡眠相关病症的PET研究。
