Maquet P, Dive D, Salmon E, Sadzot B, Franco G, Poirrier R, von Frenckell R, Franck G
Department of Neurology, University of Liège, Belgium.
Brain Res. 1990 Apr 9;513(1):136-43. doi: 10.1016/0006-8993(90)91099-3.
Using the [18F]fluorodeoxyglucose method and positron emission tomography, we studied cerebral glucose utilization during sleep and wakefulness in 11 young normal subjects. Each of them was studied at least thrice: during wakefulness, slow wave sleep (SWS) and rapid eye movement sleep (REMS), at 1 week intervals. Four stage 3-4 SWS and 4 REMS fulfilled the steady state conditions of the model. The control population consisted of 9 normal age-matched subjects studied twice during wakefulness at, at least, 1 week intervals. Under these conditions, the average difference between the first and the second cerebral glucose metabolic rates (CMRGlu was: -7.91 +/- 15.46%, which does not differ significantly from zero (P = 0.13). During SWS, a significant decrease in CMRGlu was observed as compared to wakefulness (mean difference: -43.80 +/- 14.10%, P less than 0.01). All brain regions were equally affected but thalamic nuclei had significantly lower glucose utilization than the average cortex. During REMS, the CMRGlu were as high as during wakefulness (mean difference: 4.30 +/- 7.40%, P = 0.35). The metabolic pattern during REMS appeared more heterogeneous than at wake. An activation of left temporal and occipital areas is suggested. It is hypothetized that energy requirements for maintaining membrane polarity are reduced during SWS because of a decreased rate of synaptic events. During REMS, cerebral glucose utilization is similar to that of wakefulness, presumably because of reactivated neurotransmission and increased need for ion gradients maintenance.
我们使用[18F]氟脱氧葡萄糖法和正电子发射断层扫描技术，对11名年轻正常受试者在睡眠和清醒状态下的脑葡萄糖利用情况进行了研究。他们每人至少接受了三次研究：分别在清醒、慢波睡眠（SWS）和快速眼动睡眠（REMS）状态下，间隔1周进行。四个3-4期的慢波睡眠和4次快速眼动睡眠符合模型的稳态条件。对照组由9名年龄匹配的正常受试者组成，他们在清醒状态下至少间隔1周接受了两次研究。在这些条件下，第一次和第二次脑葡萄糖代谢率（CMRGlu）的平均差异为：-7.91±15.46%，与零无显著差异（P = 0.13）。与清醒状态相比，在慢波睡眠期间观察到CMRGlu显著降低（平均差异：-43.80±14.10%，P<0.01）。所有脑区均受到同等影响，但丘脑核的葡萄糖利用率明显低于平均皮质。在快速眼动睡眠期间，CMRGlu与清醒时一样高（平均差异：4.30±7.40%，P = 0.35）。快速眼动睡眠期间的代谢模式似乎比清醒时更加不均匀。提示左侧颞叶和枕叶区域有激活。据推测，由于突触活动速率降低，慢波睡眠期间维持膜极性所需的能量需求减少。在快速眼动睡眠期间，脑葡萄糖利用与清醒时相似，可能是因为神经传递重新激活以及维持离子梯度的需求增加。
