Sokal D C, Zipper J, King T
Family Health International, Research Triangle Park, NC, USA.
Int J Gynaecol Obstet. 1995 Dec;51 Suppl 1:S57-69. doi: 10.1016/0020-7292(95)90370-4.
To review the use of quinacrine pellets for non-surgical female sterilization.
The transcervical insertion of quinacrine pellets has been under study for over 15 years. It could potentially expand access to sterilization services, because it is relatively simple to administer, with the use of a modified IUD inserter, and is inexpensive.
Published and unpublished data are reviewed.
The short-term safety of transcervical quinacrine appears to be better than surgical sterilization, but it is less effective, especially among women under 35, and there are virtually no data on its reversibility. Thus, it is probably most appropriate for older women, aged 35 and over, but it could be an option for others where access to surgical sterilization is limited.
The use of quinacrine pellets for female sterilization needs to be reviewed by appropriate regulatory authorities, especially with regard to long-term safety issues, and additional clinical studies are needed to better define a standardized regimen.
回顾喹吖因栓用于女性非手术绝育的情况。
经宫颈插入喹吖因栓的研究已开展超过15年。它有可能扩大绝育服务的可及性，因为使用改良的宫内节育器放置器给药相对简单且成本低廉。
对已发表和未发表的数据进行回顾。
经宫颈使用喹吖因的短期安全性似乎优于手术绝育，但效果较差，尤其是在35岁以下女性中，而且几乎没有关于其可逆性的数据。因此，它可能最适合35岁及以上的老年女性，但在手术绝育可及性有限的其他情况下，它也可能是一种选择。
喹吖因栓用于女性绝育需要由适当的监管机构进行审查，特别是关于长期安全性问题，并且需要更多的临床研究来更好地确定标准化方案。
