Perenboom R M, van Schijndel A C, Beckers P, Sauerwein R, Van Hamersvelt H W, Festen J, Gallati H, van der Meer J W
Department of General Internal Medicine, University Hospital Nijmegen, The Netherlands.
Eur J Clin Invest. 1996 Feb;26(2):159-66. doi: 10.1046/j.1365-2362.1996.118253.x.
Concentrations and ex vivo production of interleukin-1beta (IL-1beta), tumour necrosis factor-alpha (TNF), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1RA) and TNF soluble receptors were followed in bronchoalveolar lavage (BAL) fluid and blood from 10 HIV-seronegative patients with Pneumocystis carinii pneumonia (PCP) and compared with values found in healthy volunteers. During the acute phase of PCP, TNF but not IL-6 or IL-1beta was detectable in BAL fluid. At that time, plasma concentrations of the proinflammatory cytokines were low, whereas plasma concentrations of the anti-inflammatory cytokines were high. The ex vivo production capacity of proinflammatory cytokines was suppressed in the acute phase, in the blood as well as at the site of infection. During convalescence the production capacity of the blood cells normalized. The IL-1RA production capacity of the alveolar cells was also suppressed in the acute phase, but preserved in blood cells.
对10例患有卡氏肺孢子虫肺炎（PCP）的HIV血清阴性患者的支气管肺泡灌洗（BAL）液和血液中白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF）、白细胞介素-6（IL-6）、白细胞介素-1受体拮抗剂（IL-1RA）和TNF可溶性受体的浓度及体外产生情况进行了跟踪，并与健康志愿者的数值进行了比较。在PCP急性期，BAL液中可检测到TNF，但未检测到IL-6或IL-1β。此时，促炎细胞因子的血浆浓度较低，而抗炎细胞因子的血浆浓度较高。急性期时，促炎细胞因子的体外产生能力在血液以及感染部位均受到抑制。在恢复期，血细胞的产生能力恢复正常。急性期肺泡细胞的IL-1RA产生能力也受到抑制，但血细胞中的产生能力得以保留。
