Kischka U, Kammer T, Maier S, Weisbrod M, Thimm M, Spitzer M
Department of Neurology, University of Magdeburg, Germany.
Neuropsychologia. 1996 Nov;34(11):1107-13. doi: 10.1016/0028-3932(96)00024-3.
In order to examine the effect of dopamine on semantic processing, we performed a double-blind, placebo-controlled study. Healthy volunteers (n = 31) were tested in a lexical decision paradigm after ingestion of either L-dopa 100 mg with benserazide 25 mg or placebo. While direct semantic priming was influenced only marginally by L-dopa, the indirect priming effects was reduced significantly. These data support the hypothesis that dopamine increases the signal-to-noise ratio in semantic networks by reducing the spread of semantic processing, thereby leading to a focussing of activation.
为了研究多巴胺对语义加工的影响，我们进行了一项双盲、安慰剂对照研究。健康志愿者（n = 31）在摄入100毫克左旋多巴与25毫克苄丝肼或安慰剂后，采用词汇判断范式进行测试。虽然直接语义启动仅受到左旋多巴的轻微影响，但间接启动效应显著降低。这些数据支持了以下假设：多巴胺通过减少语义加工的扩散来提高语义网络中的信噪比，从而导致激活的聚焦。
