Huerta P T, Scearce K A, Farris S M, Empson R M, Prusky G T
Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge 02139, USA.
Neuroreport. 1996 Jul 8;7(10):1685-9. doi: 10.1097/00001756-199607080-00032.
Previous work has shown that knockout mice lacking the fyn tyrosine kinase gene (fyn-/-) are impaired in spatial learning. Here, we have re-examined the spatial learning of fyn-/- mutants in an open field water maze. Unlike wild-type mice, fyn-/- knockouts often floated without moving when placed in the water but could swim adequately when their hind feet were mechanically stimulated. Under these conditions, fyn-/- mice showed significant improvement over trials in locating a hidden platform. On a transfer trial, at the end of training, they spent a disproportionate amount of time swimming in the location of the previously hidden platform. These findings suggest that fyn-/- knockouts are capable of spatial learning, but suffer an impairment that compromises their ability to swim normally.
先前的研究表明，缺乏fyn酪氨酸激酶基因的敲除小鼠（fyn-/-）在空间学习方面存在缺陷。在此，我们在旷场水迷宫中重新检测了fyn-/-突变体的空间学习能力。与野生型小鼠不同，fyn-/-敲除小鼠被放入水中时常常漂浮不动，但当其后脚受到机械刺激时能够正常游泳。在这些条件下，fyn-/-小鼠在定位隐藏平台的试验中表现出显著的进步。在训练结束时的转移试验中，它们在先前隐藏平台的位置花费了不成比例的时间游泳。这些发现表明，fyn-/-敲除小鼠具有空间学习能力，但存在损害其正常游泳能力的缺陷。
