Reidelberger R D, Tuma D J, Woltman T A, Donohue T M
Alcohol Research Center, Veterans Administration Medical Center, Omaha, Nebraska 68105, USA.
Alcohol Clin Exp Res. 1996 Oct;20(7):1275-82. doi: 10.1111/j.1530-0277.1996.tb01123.x.
We compared the feeding patterns of rats ingesting a 36% ethanol-containing liquid diet for 30 days with those of rats pair-fed an isocaloric liquid control diet or provided control diet or ground rat chow ad libitum. Ethanol-fed rats consumed fewer calories per day and gained less body weight than rats fed control diets ad libitum. Daily caloric intakes were approximately 50% lower during the first 10 days and 20% thereafter. Lower intakes in ethanol-fed rats occurred through a decrease in mean meal size rather than number of meals per day, although meals were more evenly distributed diurnally. Pair-fed rats ingested most of their food in one or two meals within a few hours of presentation. In a related experiment, a 4-hr duodenal infusion of ethanol at a rate comparable to that of ethanol ingestion resulted in plasma ethanol levels of 28 +/- 4 mM and suppressed 5-hr intake by approximately 40% by increasing the mean postmeal interval and satiety ratio. These results suggest that the suppressive effect of ethanol ingestion on food intake may be mediated in part by a post-gastric mechanism of ethanol action.
我们将摄入含36%乙醇的液体饲料30天的大鼠的进食模式，与配对喂食等热量液体对照饲料或随意提供对照饲料或大鼠干粮的大鼠的进食模式进行了比较。与随意喂食对照饲料的大鼠相比，喂食乙醇的大鼠每天摄入的热量更少，体重增加也更少。在最初10天，每日热量摄入量约低50%，之后低20%。喂食乙醇的大鼠摄入量较低是由于平均餐量减少，而非每日餐数减少，尽管餐食在白天分布更均匀。配对喂食的大鼠在喂食后几小时内分一或两餐摄入大部分食物。在一项相关实验中，以与乙醇摄入速率相当的速度对十二指肠进行4小时乙醇灌注，导致血浆乙醇水平达到28±4 mM，并通过延长平均餐后间隔和饱腹感比例使5小时摄入量减少约40%。这些结果表明，摄入乙醇对食物摄入的抑制作用可能部分由乙醇作用的胃后机制介导。
