Kawano T, Shiraishi S, Nakamura T, Yokoo H, Takasaki M
Department of Anesthesia, Kawanishi City Hospital.
Masui. 1996 Sep;45(9):1074-7.
We compared analgesic effects of a lidocaine tape (Penles) and the eutectic mixture of lidocaine and tetracaine (LT ointment) during local infiltration before epidural block. Ninety-six patients were randomly assigned to 3 groups. In groups 1 and 2, lidocaine tape was applied on the skin of the epidural puncture site 30-60 min before epidural block. In group 3, 1 g of LT ointment was applied on the same place 1-2 h before block. Additionally, patients in groups 2 and 3 were medicated intramuscularly with midazolam 5 mg. Although no significant difference in pain relief in 5 pin prick tests was observed among the three groups, there was a significantly greater decrease in the pain score during the infiltration of local anesthetics in groups 1 and 2, compared with group 3. There was no significant difference in the pain score between groups 1 and 2. We concluded that lidocaine tape is more useful than LT ointment in decreasing pain of local infiltration anesthesia, and midazolam did not exert any supplementary analgesic effect.
我们比较了利多卡因贴剂（Penles）和利多卡因与丁卡因的共熔混合物（LT软膏）在硬膜外阻滞前局部浸润期间的镇痛效果。96例患者被随机分为3组。在第1组和第2组中，在硬膜外阻滞前30 - 60分钟将利多卡因贴剂应用于硬膜外穿刺部位的皮肤。在第3组中，在阻滞前1 - 2小时在同一部位涂抹1 g LT软膏。此外，第2组和第3组的患者肌内注射5 mg咪达唑仑。尽管在三组的5次针刺试验中未观察到疼痛缓解有显著差异，但与第3组相比，第1组和第2组在局部麻醉药浸润期间的疼痛评分显著降低。第1组和第2组之间的疼痛评分无显著差异。我们得出结论，在减轻局部浸润麻醉的疼痛方面，利多卡因贴剂比LT软膏更有用，且咪达唑仑未发挥任何辅助镇痛作用。
