Kase S, Kobayashi T, Takiguchi T, Kitajima T
Department of Anesthesia, Sano Kousei Hospital.
Masui. 1998 Sep;47(9):1080-4.
The purpose of this study is to clarify the volume effect of epidural saline injection 20 min after spinal anesthesia. Thirty patients undergoing combined spinal and epidural anesthesia for orthopedic surgery were randomly divided into two groups: a control group (n = 15) and a saline group (n = 15). In the control group, 2% lidocaine 3 ml with 0.4% tetracaine was injected into the subarachnoid space from L 4-5 interspace using Durasafe (Becton Dickinson, USA) and saline was not injected into the epidural space. In the saline group, saline 10 ml was injected through an epidural catheter 20 min after spinal anesthesia. The levels of analgesia 20 min after spinal anesthesia were not significantly different between the groups. However, the levels of analgesia 3, 5, 10, 40 and 100 min after epidural saline injection in the saline group were significantly higher than those in the control group (P < 0.05). The highest analgesic level was obtained 10 min after epidural saline injection and reached to T 4.3 +/- 1.1. In conclusion, epidural saline injection increases the analgesic level 20 min after spinal anesthesia because of the volume effect.
本研究的目的是阐明脊髓麻醉20分钟后硬膜外注射生理盐水的容量效应。30例行骨科手术的腰麻-硬膜外联合麻醉患者被随机分为两组:对照组(n = 15)和生理盐水组(n = 15)。对照组中,使用美国贝克顿·迪金森公司生产的Durasafe从L4-5间隙向蛛网膜下腔注射3 ml含0.4%丁卡因的2%利多卡因,且未向硬膜外腔注射生理盐水。在生理盐水组中,脊髓麻醉20分钟后通过硬膜外导管注射10 ml生理盐水。脊髓麻醉20分钟后两组间的镇痛水平无显著差异。然而,生理盐水组在硬膜外注射生理盐水后3、5、10、40和100分钟的镇痛水平显著高于对照组(P < 0.05)。硬膜外注射生理盐水后10分钟达到最高镇痛水平,达T4.3±1.1。总之,由于容量效应,硬膜外注射生理盐水可提高脊髓麻醉20分钟后的镇痛水平。