Koshiyama M, Yoshida M, Takemura M, Yura Y, Matsushita K, Hayashi M, Tauchi K, Konishi I, Mori T
Department of Obstetrics and Gynecology, Tenri Hospital, Nara, Japan.
Acta Obstet Gynecol Scand. 1996 Sep;75(8):702-6. doi: 10.3109/00016349609065730.
To examine the expression of sex steroid receptors (ER: estrogen receptor; PR: progesterone receptor) in the postmenopausal endometrium (PMEM) and the relationship to clinical data for studying its characters.
The immunohistochemical reactivity of the PMEM was studied using monoclonal antibodies against ER and PR, in 33 postmenopausal patients.
The endometrium was thicker in patients who were postmenopausal for 1 to 10 years (1.48 +/- 1.31 mm) than in patients who were postmenopausal for more than 10 years (0.79 +/- 0.37 mm)(p < 0.05). Among the 33 postmenopausal endometrial samples, ER positivity was found in the glands in 26 cases (78.8%) and PR positivity was detected in 18 cases (54.5%). The average age of the patients with ER positive reactivity in the glands (61.69 +/- 7.26 years) was significantly lower than that of the patients with ER negative reactivity (66.00 +/- 3.56 years)(p < 0.05). Furthermore, the endometrial thickness of the patients with ER or PR positive reactivity in the glands (1.24 +/- 1.09 mm and 1.47 +/- 1.20 mm, respectively) was significantly greater than that of the patients with ER or PR negative reactivity (0.67 +/- 0.26 mm and 0.70 +/- 0.40 mm, respectively)(p < 0.05).
ER in the glands of the PMEM was determined to decrease gradually with increased aging. The presence of ER and PR in the gland cells seemed likely to determine the thickness of the PMEM.
检测绝经后子宫内膜（PMEM）中性激素受体（ER：雌激素受体；PR：孕激素受体）的表达及其与临床数据的关系，以研究其特征。
采用抗ER和PR的单克隆抗体，对33例绝经后患者的PMEM进行免疫组化反应性研究。
绝经1至10年患者的子宫内膜厚度（1.48±1.31mm）大于绝经10年以上患者（0.79±0.37mm）（p<0.05）。在33例绝经后子宫内膜样本中，26例（78.8%）腺体中ER呈阳性，18例（54.5%）检测到PR呈阳性。腺体中ER阳性反应性患者的平均年龄（61.69±7.26岁）显著低于ER阴性反应性患者（66.00±3.56岁）（p<0.05）。此外，腺体中ER或PR阳性反应性患者的子宫内膜厚度（分别为1.24±1.09mm和1.47±1.20mm）显著大于ER或PR阴性反应性患者（分别为0.67±0.26mm和0.70±0.40mm）（p<0.05）。
PMEM腺体中的ER随年龄增长逐渐减少。腺细胞中ER和PR的存在似乎决定了PMEM的厚度。
