肾腺癌患者的腺苷脱氨酶活性

Adenosine deaminase activity in patients with renal adenocarcinoma.

作者信息

Sufrin G, Tritsch G L, Mittelman A, Moore R H, Murphy G P

出版信息

Cancer. 1977 Aug;40(2):796-802. doi: 10.1002/1097-0142(197708)40:2<796::aid-cncr2820400230>3.0.co;2-o.

DOI:10.1002/1097-0142(197708)40:2<796::aid-cncr2820400230>3.0.co;2-o

Abstract

Erythrocyte and lymphocyte adenosine deaminase (ADA) levels were studied in 31 patients with renal cell carcinoma (RCC). Decreased lymphocyte ADA levels occurred in patients with RCC. Erythrocyte ADA levels were reduced only in blood type B and O patients. Nephrectomy resulted in a rise in lymphocyte and erythrocyte ADA levels. Progression of clinical disease was associated with a fall in lymphocyte ADA values in all patients and with a rise in erythrocyte levels only in blood type A patients. Our results suggest that changes in erythrocyte and lymphocyte ADA levels in RCC patients are acquired and may offer insight into host-tumor interactions.

摘要

对31例肾细胞癌（RCC）患者的红细胞和淋巴细胞腺苷脱氨酶（ADA）水平进行了研究。RCC患者的淋巴细胞ADA水平降低。仅在B型血和O型血患者中，红细胞ADA水平降低。肾切除术导致淋巴细胞和红细胞ADA水平升高。临床疾病进展与所有患者淋巴细胞ADA值下降相关，仅在A型血患者中与红细胞水平升高相关。我们的结果表明，RCC患者红细胞和淋巴细胞ADA水平的变化是后天获得的，可能有助于深入了解宿主与肿瘤的相互作用。