Sufrin G, Tritsch G L, Mittelman A, Murphy G P
Int Adv Surg Oncol. 1978;1:11-28.
Adenosine deaminase (ADA) is a critical enzyme in purine metabolism and lymphocyte ADA activity is specifically related to immunocompetence in man. Since immunologic factors are relevant in patients with renal and transitional cell carcinoma, we studied lymphocyte ADA activity in these patients. In renal adenocarcinoma patients lymphocyte ADA activity was reduced. Such reductions were most marked in low-as compared to high-stage lesions. Nephrectomy resulted in a rise and disease progression in a decline in ADA activity. In contrast, bladder, carcinoma patients showed elevated lymphocyte ADA activity most marked in high-stage lesions. Disease progression was associated with a rise and tumor resection with a decline in lymphocyte ADA activity. Discordance in patterns of lymphocyte ADA activity when patients with renal and transitional cell carcinoma are compared suggests unique host-tumor interactions at the enzyme level. Studies of ADA may offer insight into molecular aspects of immune mechanisms.
腺苷脱氨酶（ADA）是嘌呤代谢中的一种关键酶，淋巴细胞ADA活性与人的免疫能力密切相关。由于免疫因素在肾细胞癌和移行细胞癌患者中具有相关性，我们对这些患者的淋巴细胞ADA活性进行了研究。在肾腺癌患者中，淋巴细胞ADA活性降低。与高分期病变相比，低分期病变中的这种降低最为明显。肾切除术后ADA活性升高，疾病进展时ADA活性下降。相比之下，膀胱癌患者的淋巴细胞ADA活性升高，在高分期病变中最为明显。疾病进展与淋巴细胞ADA活性升高相关，肿瘤切除后则与淋巴细胞ADA活性下降相关。比较肾细胞癌和移行细胞癌患者时淋巴细胞ADA活性模式的不一致表明在酶水平上存在独特的宿主-肿瘤相互作用。对ADA的研究可能有助于深入了解免疫机制的分子方面。
