Ringborg U, Lambert B
Cancer Lett. 1977 Jul;3(1-2):77-81. doi: 10.1016/s0304-3835(77)94333-6.
Ultraviolet-induced DNA-repair synthesis was studied in peripheral lymphocytes from 10 patients with chronic lymphatic leukemia (CLL). An ultraviolet-dose curve was established for each patient and compared with curves for healthy individuals. The same level of DNA-repair synthesis was recorded in CLL and normal lymphocytes. This contrasts with a report from another laboratory. Evidence is presented of the necessity of inhibiting replicative DNA-synthesis with hydroxyurea in order to adequately estimate the DNA-repair synthesis.
对10例慢性淋巴细胞白血病（CLL）患者外周血淋巴细胞中的紫外线诱导DNA修复合成进行了研究。为每位患者绘制了紫外线剂量曲线，并与健康个体的曲线进行比较。CLL淋巴细胞和正常淋巴细胞中的DNA修复合成水平相同。这与另一个实验室的报告形成对比。有证据表明，为了充分评估DNA修复合成，有必要用羟基脲抑制复制性DNA合成。
