Greenwood B, Rodriguez S, Decktor D, Maton P N, Robinson M
Oklahoma Foundation for Digestive Research, Presbyterian Hospital, Oklahoma City 73104, USA.
J Okla State Med Assoc. 1996 Feb;89(2):47-50.
Irritable bowel syndrome (IBS), is characterized by gastrointestinal hyperalgesia. In this study we investigated mucosal application of dyclonine on urge to defecate and pain threshold in volunteers and IBS patients (n = 10). Either saline or dyclonine (40 ml enema) was administered 10 minutes prior to rectosigmoid distension or cutaneous cold water pressor test. In IBS patients and volunteers no differences in cutaneous pain thresholds were noted. However, IBS patients had a lower pain threshold in the rectosigmoid than volunteers. In volunteers there was a significant difference between the threshold for urge to defecate and the threshold for rectosigmoid pain that was not apparent in IBS patients. Dyclonine administered directly into the rectosigmoid did not alter urge to defecate or pain threshold induced by distension in volunteers or IBS patients. These data suggest that the origin of pain perception is localized in deeper structures within the wall of the rectosigmoid colon.
肠易激综合征（IBS）的特征是胃肠道痛觉过敏。在本研究中，我们调查了在志愿者和IBS患者（n = 10）中，将达克罗宁经黏膜应用于排便冲动和疼痛阈值的情况。在进行直肠乙状结肠扩张或皮肤冷水加压试验前10分钟，给予生理盐水或达克罗宁（40毫升灌肠剂）。在IBS患者和志愿者中，未观察到皮肤疼痛阈值的差异。然而，IBS患者直肠乙状结肠的疼痛阈值低于志愿者。在志愿者中，排便冲动阈值和直肠乙状结肠疼痛阈值之间存在显著差异，而在IBS患者中并不明显。直接注入直肠乙状结肠的达克罗宁并未改变志愿者或IBS患者因扩张引起的排便冲动或疼痛阈值。这些数据表明，疼痛感知的起源位于直肠乙状结肠壁内更深的结构中。
