Brind A M, Watson J P, Burt A, Kestevan P, Wallis J, Proctor S J, Bassendine M F
The Liver Unit, Freeman Hospital, Newcastle upon Tyne, UK.
Leuk Lymphoma. 1996 Mar;21(1-2):127-30. doi: 10.3109/10428199609067589.
The hepatitis C virus (HCV) is a recently described and important cause of acute and chronic liver disease. A hallmark of HCV is its propensity to become chronic, some patients with chronic HCV progressing to cirrhosis and hepatocellular carcinoma (HCC). HCV is also lymphotrophic and we report 2 patients with HCV cirrhosis who developed non-Hodgkins lymphoma (NHL). These cases raise the possibility that chronic HCV infection of lymphocytes plays an aetiological role in this malignancy. However screening of a further 63 consecutive patients over the age of 50 years with NHL for HCV antibody by second generation enzyme linked immunoassay (ELISA) failed to identify any patients with evidence of HCV infection. This suggests that HCV is an uncommon contributory factor for the development of non-Hodgkins lymphoma in the United Kingdom.
丙型肝炎病毒（HCV）是一种最近才被发现的、引发急慢性肝病的重要病因。HCV的一个特点是它易于转为慢性，一些慢性HCV患者会发展为肝硬化和肝细胞癌（HCC）。HCV还具有嗜淋巴细胞性，我们报告了2例HCV肝硬化患者发展为非霍奇金淋巴瘤（NHL）的病例。这些病例提示淋巴细胞的慢性HCV感染可能在这种恶性肿瘤的病因学中起作用。然而，通过第二代酶联免疫吸附测定（ELISA）对另外63例年龄超过50岁的NHL患者连续进行HCV抗体筛查，未发现任何有HCV感染证据的患者。这表明在英国，HCV是导致非霍奇金淋巴瘤发生的一个不常见的促成因素。
