McColl M D, Singer I O, Tait R C, McNeil I R, Cumming R L, Hogg R B
Department of Haematology, Southern General Hospital NHS Trust, Glasgow, Scotland, UK.
Leuk Lymphoma. 1997 Jun;26(1-2):127-30. doi: 10.3109/10428199709109167.
Infection with the Hepatitis C virus (HCV) has been aetiologically linked with the lymphoproliferative disorder mixed cryoglobulinaemia and more recently with certain subgroups of B cell non-Hodgkin's lymphoma (NHL). Many of the studies which have documented the association with NHL have originated from Italy, where the background prevalence of infection with the virus is relatively high. We have performed a study, based in the West of Scotland, to determine the prevalence of infection with HCV in an unselected group of 110 individuals with lymphoproliferative disorders (72 with NHL, and 38 with chronic lymphocytic leukaemia). None of our cohort (both NHL and CLL) had evidence of infection with the virus. Our study suggests that whilst HCV may be important in the aetiology of certain subgroups of NHL, this effect may be regional and dependent upon the background prevalence of the virus in the community.
丙型肝炎病毒（HCV）感染在病因上与淋巴增殖性疾病混合性冷球蛋白血症相关，最近还与B细胞非霍奇金淋巴瘤（NHL）的某些亚组相关。许多记录了与NHL关联的研究都来自意大利，该国该病毒的感染背景患病率相对较高。我们在苏格兰西部进行了一项研究，以确定110名患有淋巴增殖性疾病的未选定个体（72名患有NHL，38名患有慢性淋巴细胞白血病）中HCV的感染率。我们的队列（包括NHL和CLL）中没有一人有该病毒感染的证据。我们的研究表明，虽然HCV在某些NHL亚组的病因中可能很重要，但这种影响可能具有区域性，并且取决于社区中该病毒的背景患病率。
