Timofeeva N M
Vestn Ross Akad Med Nauk. 1996(1):37-41.
The fact that the enzymes splitting food nutrients, those of protein nature in particular, not only in the epithelial cells of the small bowel, but in the lower structures of the intestinal wall, i.e. in the stromal and muscle serous layers, is shown for the first time. They are integral parts of the intestinal enzymatic barrier that protects the internal medium of the body from penetration of proteins and peptides. The activities of the enzymes which are present in the epithelial, stromal, and muscle serous layers have been demonstrated to be substantially changed in disorders (immobilization in the presence of starvation, surgical interventions into the small bowel). It is suggested that examining the functions of the postepithelial enzymatic barrier along with those of the epithelial and immunological ones will provide a deeper insight into some certain disorders of the alimentary tract.
首次表明，分解食物营养素的酶，尤其是分解蛋白质类营养素的酶，不仅存在于小肠上皮细胞中，还存在于肠壁的较低结构中，即在基质和肌肉浆液层中。它们是肠道酶屏障的组成部分，可保护人体内部介质免受蛋白质和肽的侵入。已经证明，上皮、基质和肌肉浆液层中存在的酶的活性在疾病（饥饿时固定不动、小肠手术干预）中会发生显著变化。有人认为，检查上皮后酶屏障以及上皮和免疫屏障的功能将有助于更深入地了解消化道的某些特定疾病。
