Gromova L V, Gusev S A, Egorova V V, Iezuitova N N, Nikitina A A, Timofeeva N M, Tsvetkova V A, Ugolev A M
Fiziol Zh SSSR Im I M Sechenova. 1991 Nov;77(11):82-93.
Proceeding from the newly obtained evidence on the distribution of digestive enzymes in mucosal, submucosal and muscular layers of the small intestine in rats, a hypothesis has been formulated: in addition to the enterocyte enzyme complex forming the epithelial barrier, there seems to exist a postepithelial barrier formed by the enzymes localized in subepithelial structures. The efficiency of this second barrier was manifested by the study of the peptide hydrolysis and transport using everted intact and de-epithelialized intestinal sacs.
基于新获得的关于大鼠小肠黏膜、黏膜下层和肌层中消化酶分布的证据，已形成一种假说：除了形成上皮屏障的肠上皮细胞酶复合物外，似乎还存在一种由位于上皮下结构中的酶形成的上皮后屏障。通过使用完整外翻和去上皮化肠囊对肽水解和转运进行研究，证实了这第二种屏障的有效性。
