Selitskaia R P, Ponomareva Iu Iu
Probl Tuberk. 1996(1):47-9.
The paper presents evaluation of HLA-system functional activity in patients with pulmonary tuberculosis and bronchial asthma by expression of class I and II antigens and beta2-microglobulin level in peripheral blood cell elements. Tuberculous patients had reduced production of beta2-microglobulin in the cell elements. Long-term chemotherapy aggravated the above abnormality. A correlation was found between changes in the cell elements expressing HLA antigens class I and II and tuberculosis course. Lowered lymphocyte count expressing HLA antigens class I and II occurs in progression of tuberculosis and is associated with marked depression of T-cell immunity.
本文通过外周血细胞成分中I类和II类抗原的表达以及β2-微球蛋白水平，对肺结核和支气管哮喘患者的HLA系统功能活性进行了评估。结核患者细胞成分中β2-微球蛋白的产生减少。长期化疗加剧了上述异常。发现表达I类和II类HLA抗原的细胞成分变化与结核病程之间存在相关性。在结核病进展过程中，表达I类和II类HLA抗原的淋巴细胞计数降低，且与T细胞免疫的显著抑制有关。
