Ueno T, Tamaki S, Sugawara H, Inuzuka S, Torimura T, Sata M, Tanikawa K
Second Department of Medicine, Kurume University School of Medicine, Fukuoka, Japan.
J Hepatol. 1996 Feb;24(2):177-84. doi: 10.1016/s0168-8278(96)80027-4.
BACKGROUND/AIMS: This study was performed to assess the significance of elevated serum tissue inhibitor of metalloproteinases-1 concentration in various liver diseases.
Tissue inhibitor of metalloproteinases-1 levels were measured in patients with various liver diseases, and were compared with serum type III procollagen-N-peptide (P III P), type IV collagen and laminin P1 levels, as well as with the histology of liver biopsy specimens.
Mean tissue inhibitor of metalloproteinases-1 levels were significantly higher in subjects with acute viral hepatitis, cirrhosis, alcoholic hepatitis, and alcoholic cirrhosis than in the control group (p < 0.05). Serum tissue inhibitor of metalloproteinases-1 levels in the various liver diseases showed positive correlation with serum type IV collagen, P III P, and laminin P1 levels. Regarding the relationship between tissue inhibitor of metalloproteinases-1 and liver histology, serum tissue inhibitor of metalloproteinases-1 levels correlated with the degree of hepatic fibrosis and inflammation, such as focal necrosis and cell infiltration. Furthermore, elevated serum tissue inhibitor of metalloproteinases-1 levels were especially related to the cell infiltration, focal necrosis, portal fibrosis, and serum type IV collagen level.
These findings suggest that the measurement of the serum tissue inhibitor of metalloproteinases-1 level in various liver diseases may be useful to estimate the active hepatic fibrogenesis associated with the active inflammatory stage of the liver injury.
背景/目的：本研究旨在评估血清金属蛋白酶组织抑制剂-1浓度升高在各种肝脏疾病中的意义。
测定各种肝脏疾病患者的金属蛋白酶组织抑制剂-1水平，并与血清III型前胶原N端肽（P III P）、IV型胶原和层粘连蛋白P1水平以及肝活检标本的组织学结果进行比较。
急性病毒性肝炎、肝硬化、酒精性肝炎和酒精性肝硬化患者的平均金属蛋白酶组织抑制剂-1水平显著高于对照组（p < 0.05）。各种肝脏疾病患者的血清金属蛋白酶组织抑制剂-1水平与血清IV型胶原、P III P和层粘连蛋白P1水平呈正相关。关于金属蛋白酶组织抑制剂-1与肝脏组织学的关系，血清金属蛋白酶组织抑制剂-1水平与肝纤维化和炎症程度相关，如局灶性坏死和细胞浸润。此外，血清金属蛋白酶组织抑制剂-1水平升高尤其与细胞浸润、局灶性坏死、门脉纤维化和血清IV型胶原水平有关。
这些发现表明，测定各种肝脏疾病患者的血清金属蛋白酶组织抑制剂-1水平可能有助于评估与肝损伤活跃炎症阶段相关的活动性肝纤维化。
